Villarrica del Espíritu Santo, is a city in Paraguay. Located in the middle of the Eastern Region of Paraguay. It is the capital and most populous c…Villarrica del Espíritu Santo, is a city in Paraguay. Located in the middle of the Eastern Region of Paraguay. It is the capital and most populous city of Guairá Department. It is located to the center west of Guairá and is bordered to the east by the towns of Mbocayaty and Yataity, to the west by Itapé and Félix Pérez, to the east by Independencia, Ñumí and Garay, and to the south by San Salvador and Borja.